Cross talk of HIF1α/YB-1 in promotes metastasis of Ewing sarcoma

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Research Article
Journal of Cellular Cancer  Volume 1, Issue 1, pages 1-9
Published: December 15, 2009

Mika H. Matsuzaki, Simon F. Kingstone, Jaroslaw Umemura

Abstract

Ewing sarcoma (ES) is a part of a larger family of round blue-cell tumors that a large body of literature exists on ES of bone. Highly metastatic cancers that most often strike teens, and can be found in younger children and adults. Recent research has added numerous new proteins than can direct the metastatic process either directly or indirectly by inducing type of protein leading to death in cancer patients. Among them Y-box–binding protein-1 (YB-1) is a recently identified protein known to induce metastasis in different cancers. YB-1 mainly involved in regulation of mRNA transcription, splicing, translation, and stability. However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which YB-1 promote HIF1α-induced invasion and metastasis of Ewing sarcoma.

Keywords: Ewing sarcoma; Y-box–binding protein-1; Hypoxia-inducible factor 1α

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