MMP-9-induces macrophages in breast cancer cell via IL-10

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Research Article
Journal of Cellular Cancer  Volume 6, Issue 1, pages 14-25
Published: June 14, 2014

Christa Deng, Vitam Verbruggen, Grace Hullmann, Gabriel Tyritzis, John Shimizu

Abstract

Macrophage is one of the infiltrating inflammatory cells and promote breast cancer tumor progression via enhancement of tumor angiogenesis. In this study, we investigated whether sesamin inhibited macrophage-enhanced proangiogenic activity of breast cancer cell linesIn this study we analyzed the pattern of expression of MMP-9 and IL-10 in breast cancer tumors and prognostic significance of each marker and the effect of the interactions macrophage signaling pathway. Highlighting the importance of macrophage-enhanced angiogenic activity of breast cancer cells via MMP-9/IL-10 in such cellular crosstalk, this work offers new considerations to the establishment of more efficient therapeutic strategies, aiming to impair breast cancer invasion and progression.

Keywords: Breast cancer; Macrophage; MMP-9; IL-10

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Christa Deng, Vitam Verbruggen, Grace Hullmann, Gabriel Tyritzis, John Shimizu. MMP-9-induces macrophages in breast cancer cell via IL-10. Journal of cellular cancer 2014; 6(1):14-25.