Potential role of circulating miRNAs as biomarkers in solid tumor

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Journal of Cellular Cancer  Volume 6, Issue 2, pages 39-57
Published: December 11, 2014

Jung Zhang, Kai-Li Feng,Ting Wang, Shan Young-Kyun, Liu Yan, Chung Tae-Young  

Abstract

MiRNAs modulate the expression of tumor suppressor genes as well as oncogenes. The identification of stable miRNAs in bodily fluids paved the way for their use as novel biomarkers amenable to clinical diagnosis in translational medicine. Identification of miRNAs in exosomes that are functional upon delivery to the recipient cells has highlighted a novel method of intercellular communication. In the present review, we focus on recent advancements in the discovery and development of miRNA-based cancer therapeutics using these 2 approaches. In addition, we summarize selected studies, in which modulation of miRNA activity in preclinical cancer models in vivo has demonstrated promising therapeutic potential.

Keywords: MiRNAs; Cancer; Oncogenes; Preclinical cancer models

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RJung Zhang, Kai-Li Feng,Ting Wang, Shan Young-Kyun, Liu Yan, Chung Tae-Young. Potential role of circulating miRNAs as biomarkers in solid tumor. Journal of cellular cancer 2014; 6(2):39-57.