Relationship between LN density and clinical outcome in LN-positive patients with gastric cancer following gastrectomy

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Journal of Cellular Cancer  Volume 3, Issue 1, pages 1-15 June 2011

Jan Chen, Nan Lee, Wang Liu, Song Zheng, Mao Zhao

Abstract

Gastric cancer is difficult to cure unless it is found at an early stage (before it has begun to spread). Unfortunately, because early gastric cancer causes few symptoms, the disease is usually advanced when the diagnosis is made. Surgery remains the only curative therapy for gastric cancer. We investigate the relationship between LN density and clinical outcome in patients with LN-positive disease, following gastrectomy for gastric cancer. The Institute for Scientific Information Web of Science, PubMed, SCOPUS, and the Cochrane Library were searched to identify relevant published literature. The data from this study indicate that LN density is an independent predictor of clinical outcome in LN-positive patients. Further, LN density may be useful in future staging systems and better prognostic classification of LN-positive gastric cancer.

Keywords: Gastric cancer; Web of Science; PubMed; SCOPUS; Lymph nodes

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