Effectivness of Bruton tyrosine kinase in treatment of chronic lymphocytic leukemia

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Journal of Cellular Cancer  Volume 5, Issue 2, pages 20-31
Published: December 13, 2013

Kanti W. Christos, Nasser Ghaly Yousif, Carol Tolksdorf, Gregory A. Jones, Steven Delforge  

Abstract

Chronic lymphocytic leukemia (CLL) is a clonal malignancy of mature B cells that displays a great clinical heterogeneity, and gene-expression profiling and phenotypic studies suggest that CLL is probably derived from CD5+ B cells similar to those found in the blood of healthy adults. Agents that can interfere with B-cell receptor (BCR) signaling or chemokine– receptor signaling, or that target surface antigens selectively expressed on CLL cells, promise to have significant therapeutic benefit in patients with this disease. Downstream of the BCR is Bruton tyrosine kinase (BTK), a signal-transduction kinase that plays a critical role in BCR signaling and B-cell development and function. Loss of BTK in the human disease Bruton X-linked agammaglobulinemia results in the absence of B cells and profound hypogammaglobulinemia. Selective BTK inhibition is an attractive approach for CLL driven by BCR activation. This review has identified the role of BTK in treatment of CLL.

Keywords: Chronic lymphocytic leukemia (CLL); B-cell receptor (BCR); Bruton tyrosine kinase (BTK)

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Kanti W. Christos, Nasser Ghaly Yousif, Carol Tolksdorf , Gregory A. Jones, Steven Delforge. Effectivness of Bruton tyrosine kinase in treatment of chronic lymphocytic leukemia. Journal of Cellular Cancer 2013; 5(2): 20-31.