Epithelial polarity attenuates gastric cancer/therapeutic interventions

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Review Article
Journal of Cellular Cancer  Volume 6, Issue 1, pages 1-13
Published: June 04, 2014

Elisabeth S. Gillespie,Timothy H. Rong, Kevin Phesse, Elena Fetler, Kyung Soon Wang

Abstract

Gastric adenocarcinoma is the second leading cause of cancer-related death in the world. Epithelial cells form intercellular adhesions, characteristically exhibit apicobasal polarity, and orient their mitotic spindles in the plane of the epithelial sheet. Defects in these attributes result in the tissue disorganization associated with cance and resulting in loss of epithelial polarity, which often correlates in extent with the aggressiveness of the tumor. We review how the polarity strategies integrates and used by gastric cancer and role in therapy, this needs to understanding more mechanistic of gastric cancers which should result in better targets for gastric cancer therapy.

Keywords: Gastric cancer; Polarity; Intercellular adhesions; Mitosis; Cancer

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Elisabeth S. Gillespie,Timothy H. Rong, Kevin Phesse, Elena Fetler, Kyung Soon Wang. Epithelial polarity attenuates gastric cancer/therapeutic interventions. Journal of Cellular Cancer 2014; 6(1):1-13.